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Oxycodone is a combination of opioid and non-opioid pain-relieving formulation that helps to eliminate pain symptoms and make a person feel less pain. It amplifies the amount of GABA (gamma-aminobutyric acid). This neurotransmitter blocks the impulses between the nerve cells and the brain and changes how the brain responds to pain. It also slows down or quits the unusual activities of the brain and stops the feeling of pain.